About the 1st HUPO-HIPP summer school:
Fostered by advances in mass spectrometry (MS) and bioinformatics, immunopeptidomics –the comprehensive characterization of HLA-associated peptides – has experienced a dramatic progress over the last years. Currently, MS-based immunopeptidomics pipelines allow the profiling of HLA-bound peptidomes at an unprecedented scale. Therefore, this approach has gained increasing importance in the development of personalized immunotherapy strategies and it is expected to influence the treatment of cancer and other diseases.
The Human Immuno-Peptidome Project (HIPP) initiative (Caron et al., Immunity 2017) was created in 2017, allowing some of the most active researchers in immunopeptidomics to meet and discuss the opportunity of creating a group under the umbrella of the Human Proteome Organization (HUPO). This community has recognized that the implementation of robust analytical workflows is a major hurdle to the expansion of the field.
To circumvent this limitation and to disseminate the expertise on currently adopted methods by the immunopeptidomics community, the 1st HUPO-HIPP summer school was launched.
Thus, the major goal of the summer school is to provide attendees with critical information about the main challenges of immunopeptidomics approaches with special emphasis on sample preparation, LC-MS/MS analysis, bioinformatics and data sharing. Most importantly, this initiative will contribute to boost the accessibility to immunopeptidomic technologies and to open this scientific niche to a bigger audience.